Table 13.
Associations Between Inflammatory 1–6 Month Standardized Means and Dichotomized 6-month GOS group Using Univariate Logistic Regression.
| Standardized Month 1–6 Mean | Unfavorable 6-month GOS Score | Full Treelet (33 markers) Cluster Membership | |
|---|---|---|---|
| OR | p-value | ||
| IL-7 | 1.54 | 0.0146 | TC1: Adaptive |
| IL-21 | 1.49 | 0.0181 | TC1: Adaptive |
| IL-1b | 1.32 | 0.0908 | TC2: Innate |
| MIP-3a | 1.71 | 0.0355 | TC2: Innate |
| MIP-1b | 1.75 | 0.0326 | TC2: Innate |
| sIL-2Ra | 1.45 | 0.0500 | TC3: Soluble Molecules |
| sTNFRII | 1.64 | 0.0111 | TC3: Soluble Molecules |
| ITAC | 1.63 | 0.0277 | TC5: Chemokines |
| RANTES | 1.71 | 0.0089 | TC5: Chemokines |
| MIP-1a | 2.15 | 0.0022 | DNC |
| sICAM-1 | 1.54 | 0.0187 | DNC |
| sIL-4R | 0.60 | 0.0150 | DNC |
| *DNC: Did not cluster | |||
Only markers indicating a relationship to GOS at a threshold of p < 0.1 are reported. All markers, except sIL-4R, show increased odds of unfavorable outcome with higher expression. TC membership, based on the TT dendrogram generated from all 33 markers, is reported for reference in order to assess independent contribution of markers from each cluster in outcome distinction.