Table 1.
Application of chitosan/alginate nanocarriers in the treatment of colitis.
| Innovation points | Advantage | Particle size (nm) | Content (%) | Encapsulation efficiency (%) | Ref |
|---|---|---|---|---|---|
| PH-dependent release of curcumin from CAP1AG4 CH5@CUNCs | Enhanced accumulation in the inflamed colonic tissues | 421 ± 14 | 20–80 | 90 | (Oshi et al., 2020) |
| CD-Cur-CANPs with pH-sensitive and α-amylase-responsive release character-istics | Strong colonic biodistribution and accumulation, rapid macrophage uptake, promoted colonic epithelial barrier integrity and modulated production of inflammatory cytokines | 462.1 | 3.49 | 88.89 | (Li et al., 2021) |
| A pH-sensitive hydrogel formed by chitosan and sodium alginate under the mechanochemical force | 5-ASA colon-targeted delivery system without a crosslinking agent | 489.57 ± 118.07 | 3.77 | – | (Xu et al., 2021) |
| Novel pH-sensitive hydrogel beads based on gelatin/sodium alginate/ chitosan loaded with propolis ethanolic extracts | Synthesis of pH-sensitive hydrogel beads for different propolis ethanolic extracts | 106 −2 × 106 | – | – | (Ceylan et al., 2021) |
| A series of curcumin loaded polymeric nanoparticle (NPs) with different particle sizes | The surface functionalization of PF127 can enable NPs to penetrate through the mucus layer Improve the cellular uptake efficiency of NPs by macrophages |
185–884 | 5.1–6.1 | 73.2–89.6 | (Zhou et al., 2020) |