Table 2. Association between log of klotho concentration and several health statuses (pg/mL).

N

Unadjusted Model

Adjusted Model 1a

Adjusted Model 2b

Adjusted Model 3c

Adjusted Model 4d

Beta

SE

p-value

Beta

SE

p-value

Beta

SE

p-value

Beta

SE

p-value

Beta

SE

p-value

Uric acid

Per one-unit increase

11734

−0.034

0.003

<.0001*

−0.034

0.004

<.0001*

−0.034

0.004

<.0001*

−0.033

0.003

<.0001*

−0.028

0.004

<.0001*

Hyperuricemia

No

9092

Reference

Reference

Reference

Reference

Reference

Yes

2642

−0.085

0.009

<.0001*

−0.08

0.009

<.0001*

−0.079

0.009

<.0001*

−0.075

0.009

<.0001*

−0.062

0.009

<.0001*

History of gout

No

11031

Reference

Reference

Reference

Reference

Reference

Yes

703

−0.074

0.021

0.0006*

−0.054

0.012

0.0089*

−0.049

0.02

0.0176*

−0.046

0.02

0.0237*

−0.039

0.019

0.0443*

Hyperuricemia in the group with a history of gout

No

386

Reference

Reference

Reference

Reference

Reference

Yes

317

−0.072

0.026

0.0059*

−0.067

0.027

0.0141*

−0.073

0.029

0.0148*

−0.07

0.031

0.0258*

−0.043

0.030

0.1462

^aModel 1: Adjusted for age, gender, ethnicity. ^bModel 2: Model 1 + Adjusted for disease history (history of diabetes, hypertension, kidney disease, and malignancy). ^cModel 3: Model 2 + Adjusted for education, family income, exercise, alcohol, smoking, and obesity. ^dModel 4: Model 3 + Adjusted for kidney function(eGFR). ^*p < 0.05.