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. 2022 Mar 21;14(6):2507–2512. doi: 10.18632/aging.203966

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Copyright: © 2022 Suzuki et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Immunofluorescence staining of the liver. Red signifies IL-6. IL-6 expression is observed along the wall of the interlobular vein. The 67-week-old mice joined with 4-week-old mice have decreased fluorescence compared to the 67-week-old mice joined with 8-week mice, suggesting that there is an effect of parabiosis on younger individuals. Abbreviations: CY: control young; CO: control old; O w/4: 67-week-old mice joined with 4-week-old mice; O w/8: 67-week-old mice joined with 8-week-old mice.