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. 2022 Mar 29;12:852515. doi: 10.3389/fonc.2022.852515

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Copyright © 2022 Liu, Xu, Li, Yu, Feng, Xu and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NEAT1 serves as sponge for miR‑10a-5p in kidney cancer cells. (A) Prediction the target sequence of NEAT1 bonding to miR-10a-5p by starBase; (B) Dual luciferase reporter gene assays verify the direct binding of miR-10a-5p to NEAT1 target sequence; (C) FISH assays confirm that NEAT1 co-localizes with miR-10a-5p in the cytoplasm of kidney cancer cells; (D) Validation the efficiency of miR-10a-5p mimic and inhibitor by RT-qPCR; (E) Knockdown of NEAT1 enhances the expression of miR-10a-5p; (F, G) miR-10a-5p inhibitor reverses the inhibition of cell proliferation caused by siNEAT1. ns, not significant, p ≥ 0.05; *p < 0.05; **p < 0.01; ***p < 0.001.