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. 2022 Mar 31;20(3):e3001590. doi: 10.1371/journal.pbio.3001590

Table 1. High-confidence validated PPT1 substrates.

Protein name (UniProt ID) Gene name Description Palmitome ratio Palmitome p-value Proteome ratio Proteome p-value CRAPome (%) Kang and colleagues Swiss Palm (%) CSS Palm
AT1A1_MOUSE Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 1.831 0.007 0.960 0.318 10.949 5.882 X
AT1A2_MOUSE Atp1a2 Sodium/potassium-transporting ATPase subunit alpha-2 1.744 0.003 1.068 0.498 22.871 5.882
AT1A3_MOUSE Atp1a3 Sodium/potassium-transporting ATPase subunit alpha-3 1.746 0.030 1.042 0.695 24.574 5.882
AT1B1_MOUSE Atp1b1 Sodium/potassium-transporting ATPase subunit beta-1 2.180 0.019 0.982 0.536 0.243 X 5.882
AT1B2_MOUSE Atp1b2 Sodium/potassium-transporting ATPase subunit beta-2 6.852 0.018 1.043 0.471 0.000 X 5.882 X
ATPO_MOUSE Atp5po ATP synthase subunit O, mitochondrial 6.138 0.044 1.060 0.277 0.000 X 5.882
BASI_MOUSE Bsg Basigin 2.695 0.016 0.927 0.101 9.732 X 5.882 X
CADM2_MOUSE Cadm2 Cell adhesion molecule 2 1.975 0.004 0.988 0.559 0.000 11.76 X
CD81_MOUSE Cd81 CD81 antigen 2.554 0.042 1.035 0.940 0.243 29.41
CISD1_MOUSE Cisd1 CDGSH iron-sulfur domain-containing protein 1 1.920 0.050 0.992 0.635 1.703 35.29
DYL2_MOUSE Dynll2 Dynein light chain 2, cytoplasmic 4.192 0.027 0.996 0.808 9.246 0 X
GBB2_MOUSE Gnb2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 2.963 0.003 0.985 0.636 15.329 2.92 X
GPM6A_MOUSE Gpm6a Neuronal membrane glycoprotein M6-a 5.625 0.007 1.043 0.658 0.243 X 5.882 X
GRIA1_MOUSE Gria1 Glutamate receptor 1 1.866 0.046 0.992 0.635 0.000 X 5.882 X
KCRB_MOUSE Ckb Creatine kinase B-type 1.815 0.029 0.959 0.242 39.659 11.76
LDHB_MOUSE Ldhb L-lactate dehydrogenase B chain 1.928 0.050 1.006 0.939 39.903 X 11.76
LGI1_MOUSE Lgi1 Leucine-rich glioma-inactivated protein 1 2.047 0.013 1.014 0.883 0.000 X 11.76 X
NDKA_MOUSE Nme1 Nucleoside diphosphate kinase A 5.185 0.020 1.058 0.169 29.927 29.41
NDUS1_MOUSE Ndufs1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial 1.859 0.005 0.967 0.283 4.623 29.41 X
NFASC_MOUSE Nfasc Neurofascin 1.524 0.033 1.028 0.745 0.000 X 35.29 X
NRCAM_MOUSE Nrcam Neuronal cell adhesion molecule 1.714 0.011 1.148 0.314 0.000 35.29 X
NTRI_MOUSE Ntm Neurotrimin 4.060 0.033 0.988 0.574 0.000 X 47.06 X
STXB1_MOUSE Stxbp1 Syntaxin-binding protein 1 1.752 0.036 1.058 0.358 0.487 7.056 X
THY1_MOUSE Thy1 Thy-1 membrane glycoprotein 3.357 0.022 1.069 0.541 0.487 17.65
VDAC2_MOUSE Vdac2 Voltage-dependent anion-selective channel protein 2 2.929 0.029 0.946 0.058 14.112 X 35.29 X
VISL1_MOUSE Vsnl1 Visinin-like protein 1 2.451 0.040 0.912 0.039 0.243 X 41.18 X

X = validation of given dataset; blank cells or a score of zero indicate lack of identification in that dataset [12,31,39,97]. SwissPalm score indicates percentage of palmitoylation experiments in which the protein has been identified.