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. 2022 Apr 12;17(4):e0261165. doi: 10.1371/journal.pone.0261165

Fig 5. Manhattan plots of significance scores from single-variant analysis of exome sequencing data of patients selected from extremes of the CZP response distribution.

Fig 5

In panel A, 19 CZP super-responders are compared to 55 non-responders. Panel B shows FET significance scores for 19 CZP super-responders compared to sequence data from a larger group of 1546 ethnically matched population controls and 55 non-responders, while panel C shows results of analysis of 55 CZP non-responders versus 1546 ethnically matched population controls and 19 super-responders. Horizontal red lines in figures A-C indicate the Bonferroni-corrected threshold for statistical significance.