Table 4. SNPs previously associated with therapeutic response to TNF inhibitors.
| SNP | PUBMEDID | Region | Nearest Gene | Genotyped/ Imputed | P-value (ACR20 Wk6) | P-value (DAS28 Wk6) | P-value (DAS28 Wk12) | P-value (RD28 Wk 6) |
|---|---|---|---|---|---|---|---|---|
| rs1800896 | 18615156 | 1q32.1 | IL19 | Genotyped | 0.398 | 0.3498 | 0.6376 | 0.1547 |
| rs1800629 | 18615156 | 6p21.33 | TNF | Genotyped | 0.4269 | 0.5255 | 0.3321 | 0.78 |
| rs983332 | 18615156 | 1p22.3 | LMO4 | Genotyped | 0.8091 | 0.7796 | 0.6857 | 0.2909 |
| rs928655 | 18615156 | 1p22.2 | GBP6 | Genotyped | 0.1043 | 0.1377 | 0.1266 | 0.1585 |
| rs13393173 | 18615156 | 2q24.3 | CERS6 | Genotyped | 0.5742 | 0.1443 | 0.1691 | 0.1655 |
| rs437943 | 18615156 | 4p15.1 | ARAP2 | Genotyped | 0.7274 | 0.2707 | 0.429 | 0.3062 |
| rs10945919 | 18615156 | 6q26 | QKI | Genotyped | 0.579 | 0.1387 | 0.0937 | 0.2423 |
| rs854555 | 18615156 | 7q21.3 | PON1 | Genotyped | 0.5385 | 0.557 | 0.9665 | 0.9778 |
| rs854548 | 18615156 | 7q21.3 | PPP1R9A | Genotyped | 0.2678 | 0.6907 | 0.5764 | 0.5743 |
| rs854547 | 18615156 | 7q21.3 | PPP1R9A | Genotyped | 0.3115 | 0.6884 | 0.7034 | 0.6514 |
| rs7046653 | 18615156 | 9p21.2 | MOB3B | Genotyped | 0.8241 | 0.4069 | 0.1583 | 0.3181 |
| rs868856 | 18615156 | 9p21.2 | MOB3B | Genotyped | 0.8859 | 0.5538 | 0.1812 | 0.3844 |
| rs774359 | 18615156 | 9p21.2 | C9ORF72 | Genotyped | 0.8746 | 0.358 | 0.1237 | 0.4198 |
| rs2814707 | 18615156 | 9p21.2 | MOB3B | Genotyped | 0.7717 | 0.4574 | 0.09011 | 0.3859 |
| rs3849942 | 18615156 | 9p21.2 | C9ORF72 | Genotyped | 0.8352 | 0.2486 | 0.06975 | 0.3508 |
| rs6028945 | 18615156 | 20q12 | MAFB | Genotyped | 0.04575 | 0.3062 | 0.681 | 0.4589 |
| rs6138150 | 18615156 | 20p11.21 | CST5 | Genotyped | 0.7479 | 0.4045 | 0.6091 | 0.3948 |
| rs6071980 | 18615156 | 20q12 | MAFB | Genotyped | 0.005448 | 0.2701 | 0.8796 | 0.157 |
| rs2372536 | 20847201 | 2q35 | ATIC | Imputed | 0.4728 | 0.3225 | 0.8358 | 0.8671 |
| rs1127354 | 20847201 | 20p13 | ITPA | Imputed | 0.8614 | 0.573 | 0.04869 | 0.4101 |
| rs1801133 | 20847201 | 1p36.22 | MTHFR | Genotyped | 0.9395 | 0.8252 | 0.5648 | 0.4344 |
| rs10919563 | 20847201 | 1q32.1 | PTPRC | Imputed | 0.6454 | 0.04959 | 0.1749 | 0.008771 |
| rs12081765 | 21061259 | 1q23.3 | RXRG | Genotyped | 0.08769 | 0.4604 | 0.9424 | 0.3248 |
| rs1532269 | 21061259 | 5p13.3 | PDZD2 | Imputed | 0.06234 | 0.1323 | 0.6655 | 0.6793 |
| rs17301249 | 21061259 | 6q23.2 | EYA4 | Imputed | 0.2642 | 0.7368 | 0.8703 | 0.5782 |
| rs7305646 | 21061259 | 12p12.3 | LMO3 | Genotyped | 0.9131 | 0.7942 | 0.6261 | 0.8969 |
| rs4694890 | 21061259 | 4p11 | TEC | Genotyped | 0.9198 | 0.7517 | 0.04464 | 0.3293 |
| rs1350948 | 21061259 | 11p14.3 | CCDC179 | Genotyped | 0.7382 | 0.907 | 0.6072 | 0.9468 |
| rs4411591 | 23233654 | 18p11.31 | LOC100130480 | Imputed | 0.9059 | 0.2898 | 0.1311 | 0.5541 |
| rs7767069 | 23233654 | 6q12 | LOC102723883 | Imputed | 0.1295 | 0.1288 | 0.7267 | 0.494 |
| rs4651370 | 23233654 | 1q31.1 | PLA2G4A | Imputed | 0.1486 | 0.6554 | 0.6513 | 0.2614 |
| rs1813443 | 23233654 | 11q22.1 | CNTN5 | Imputed | 0.1955 | 0.01845 | 0.05309 | 0.06672 |
| rs1447722 | 23233654 | 3q23 | CLSTN2 | Imputed | 0.6619 | 0.2028 | 0.114 | 0.8809 |
| rs1568885 | 23233654 | 7p21.3 | ETV1 | Imputed | 0.5729 | 0.8817 | 0.8937 | 0.7815 |
| rs12142623 | 23233654 | 1q31.1 | PLA2G4A | Imputed | 0.3175 | 0.6917 | 0.6671 | 0.4263 |
| rs2378945 | 23233654 | 14q12 | NUBPL | Imputed | 0.1607 | 0.4346 | 0.7431 | 0.1113 |
| rs10520789 | 22569225 | 15q26.2 | NR2F2 | Imputed | 0.4158 | 0.5916 | 0.9036 | 0.3318 |
| rs11870477 | 22569225 | 17q24.3 | KCNJ16 | Genotyped | 0.6034 | 0.3105 | 0.9661 | 0.5014 |
| rs16973982 | 22569225 | 15q26.2 | NR2F2 | Imputed | 0.2349 | 0.8241 | 0.6655 | 0.6806 |
| rs12001550 | 22569225 | 9q33.1 | TLR4 | Imputed | 0.2199 | 0.6921 | 0.216 | 0.1803 |
| rs885814 | 22569225 | 1p36.12 | ALPL | Genotyped | 0.4722 | 0.8331 | 0.39 | 0.6981 |
| rs2293137 | 22569225 | 3p13 | FOXP1 | Imputed | 0.9456 | 0.7823 | 0.6059 | 0.5943 |
| rs885813 | 22569225 | 1p36.12 | ALPL | Genotyped | 0.2844 | 0.4211 | 0.6313 | 0.1756 |
| rs1875620 | 22569225 | 9q22.1 | C9ORF47 | Genotyped | 0.3423 | 0.2853 | 0.4925 | 0.7107 |
| rs11525966 | 22569225 | 9q22.1 | C9ORF47 | Imputed | 0.2175 | 0.3616 | 0.751 | 0.6859 |
| rs960902 | 22569225 | 2p22.2 | QPCT | Genotyped | 0.6766 | 0.9054 | 0.4399 | 0.7923 |
| rs1539909 | 22569225 | 18q22.3 | CBLN2 | Genotyped | 0.6148 | 0.4174 | 0.8415 | 0.5087 |
| rs11124586 | 22569225 | 2p22.2 | CDC42EP3 | Genotyped | 0.7767 | 0.8684 | 0.747 | 0.2929 |
| rs17679567 | 22569225 | 16q23.1 | CNTNAP4 | Genotyped | 0.5491 | 0.6337 | 0.6196 | 0.9315 |
| rs1827596 | 22569225 | 2q14.3 | CNTNAP5 | Imputed | 0.9189 | 0.7095 | 0.1244 | 0.9499 |
| rs4412918 | 22569225 | 15q21.3 | PRTG | Imputed | 0.2184 | 0.6313 | 0.6727 | 0.7144 |
| rs17002731 | 22569225 | 4q21.1 | CXCL13 | Genotyped | 0.9293 | 0.1418 | 0.8304 | 0.07673 |
| rs1835353 | 22569225 | 2q14.3 | CNTNAP5 | Genotyped | 0.5036 | 0.406 | 0.1828 | 0.4105 |
| rs6427528 | 23555300 | 1q23.3 | CD84 | Imputed | 0.7892 | 0.5482 | 0.2071 | 0.779 |
| rs1503860 | 23555300 | 1q23.3 | CD84 | Imputed | 0.8815 | 0.5997 | 0.1289 | 0.5712 |
| rs12570744 | 23555300 | 10p14 | LINP1 | Genotyped | 0.2621 | 0.4243 | 0.4004 | 0.08183 |
| rs7141276 | 23555300 | 14q13.1 | SNX6 | Imputed | 0.3357 | 0.4961 | 0.4497 | 0.2217 |
| rs10833455 | 23555300 | 11p15.1 | NELL1 | Imputed | 0.7821 | 0.3469 | 0.6566 | 0.8805 |
| rs10833456 | 23555300 | 11p15.1 | NELL1 | Imputed | 0.6108 | 0.255 | 0.719 | 0.9805 |
| rs7932820 | 23555300 | 11p15.1 | NELL1 | Imputed | 0.6176 | 0.3293 | 0.5869 | 0.8421 |
| rs8009551 | 23555300 | 14q13.1 | SNX6 | Genotyped | 0.2048 | 0.4228 | 0.4865 | 0.1568 |
| rs4336372 | 23555300 | 5q35.2 | DRD1 | Genotyped | 0.9886 | 0.8532 | 0.01123 | 0.8786 |
| rs10265155 | 23555300 | 7q21.11 | MAGI2 | Genotyped | 0.04158 | 0.04413 | 0.5201 | 0.3038 |
| rs1990099 | 23555300 | 7q21.11 | MAGI2 | Imputed | 0.2394 | 0.03951 | 0.6735 | 0.2659 |
| rs284515 | 26776603 | 6q15 | MAP3K7 | Imputed | 0.1955 | 0.8197 | 0.09406 | 0.4495 |
| rs75908454 | 26776603 | 6q27 | WDR27 | Imputed | 0.21 | 0.08461 | 0.891 | 0.8489 |
| rs1679568 | 26776603 | 10q25.3 | GFRA1 | Imputed | 0.5555 | 0.6671 | 1 | 0.9108 |
| rs284511 | 26776603 | 6q15 | MAP3K7 | Imputed | 0.8658 | 0.1713 | 0.8586 | 0.03014 |
| rs6941263 | 25896534 | 6q21 | ARMC2 | Imputed | 0.359 | 0.2057 | 0.3872 | 0.132 |
| rs113878252 | 25896534 | 22q11.21 | MED15 | Imputed | 0.1638 | 0.2092 | 0.9521 | 0.3039 |
| rs6065221 | 25896534 | 20q12 | MAFB | Genotyped | 0.7959 | 0.3276 | 0.2482 | 0.5876 |
| rs7195994 | 30166627 | 16q12.2 | FTO | Imputed | 0.9607 | 0.8829 | 0.7041 | 0.2118 |
| rs10739537 | 30166627 | 9q33.1 | DBC1 | Imputed | 0.4139 | 0.4443 | 0.6199 | 0.4562 |
| rs948138 | 30166627 | 11q22.2 | MMP20 | Genotyped | 0.3166 | 0.4068 | 0.7111 | 0.7946 |
| rs11599217 | 30166627 | 10q26.2 | DOCK1 | Imputed | 0.8675 | 0.8999 | 0.9294 | 0.9163 |
| rs2187874 | 30166627 | 4p16.3 | ZNF595 | Imputed | 0.1811 | 0.5109 | 0.5323 | 0.2259 |
| rs150537045 | 30166627 | 8q23.3 | CSMD3 | Imputed | 0.5835 | 0.4199 | 0.3298 | 0.7194 |
| rs76668869 | 30166627 | 1p31.1 | ADGRL2 | Imputed | 0.4255 | 0.164 | 0.7019 | 0.05351 |
| rs2295463 | 30166627 | 14q13.2 | KIAA0391 | Imputed | 0.4716 | 0.6512 | 0.3877 | 0.8045 |
| rs34619498 | 30166627 | 4q24 | EMCN | Imputed | 0.2414 | 0.2441 | 0.2936 | 0.6553 |
| rs140142800 | 30166627 | 10q21.2 | RHOBTB1 | Imputed | 0.8841 | 0.9169 | 0.4225 | 0.664 |
| rs78368496 | 30166627 | 11p15.1 | NAV2 | Imputed | 0.3588 | 0.7284 | 0.4222 | 0.9777 |
| rs147859879 | 30166627 | 5p15.33 | MRPL36 | Imputed | 0.6686 | 0.3167 | 0.557 | 0.12 |
| rs337527 | 30166627 | 9q22.33 | GABBR2 | Imputed | 0.2747 | 0.441 | 0.1885 | 0.8569 |
| rs11045392 | 22569225 | 12p12.2 | PDE3A | Genotyped | 0.5394 | 0.01316 | 0.06091 | 0.2323 |
| rs3794271 | 22569225 | 12p12.2 | SLCO1C1 | Genotyped | 0.4297 | 0.006361 | 0.04621 | 0.1448 |