Table 5. Top ten most strongly associated individual variants from whole exome sequencing.
| Variant | Gene | P-value | |
|---|---|---|---|
| Responders vs. Non-responders + Controls | 6_80228535_G | LCA5 | 8.541E-006 |
| 2_26689619_A | OTOF | 5.046E-005 | |
| X_49082499_T | CACNA1F | 1.03E-004 | |
| 3_113376202_C | KIAA2018 | 1.34E-004 | |
| 9_136305552_A | ADAMTS13 | 1.34E-004 | |
| 11_3661588_3661588_1bp_INS | ART5 | 1.346E-004 | |
| 12_53448166_T | TENC1 | 1.362E-004 | |
| 19_47910643_T | MEIS3 | 1.362E-004 | |
| 5_140237030_G | PCDHA10 | 1.365E-004 | |
| 21_47836571_T | PCNT | 1.469E-004 | |
| Non-responders vs. Responders + Controls | 17_73520485_C | TSEN54 | 6.133E-006 |
| 11_76062206_C | PRKRIR | 3.811E-005 | |
| 17_72240177_G | TTYH2 | 7.369E-005 | |
| 9_35663069_T | ARHGEF39 | 1.487E-004 | |
| 17_33690160_T | SLFN11 | 1.487E-004 | |
| 19_15587345_C | PGLYRP | 1.852E-004 | |
| 2_167055393_C | SCN9A | 1.877E-004 | |
| 16_24564879_24564882_4bp_DEL | RBBP6 | 2.213E-004 | |
| 14_20711681_A | OR11H4 | 2.256E-004 | |
| 6_32797809_T | TAP2 | 2.35E-004 | |
| Responders vs. Non-responders | 11_71249125_71249145_21bp_INS | KRTAP5-8 | 1.257E-006 |
| 19_7528734_G | ARHGEF18 | 1.362E-004 | |
| 9_712156_G | KANK1 | 2.466E-004 | |
| 2_196720705_C | DNAH7 | 3.06E-004 | |
| 6_25914853_A | SLC17A2 | 4.977E-004 | |
| 19_51530741_G | KLK11 | 9.068E-004 | |
| 2_220072431_A | ZFAND2B | 9.082E-004 | |
| 2_32713706_T | BIRC6 | 9.897E-004 | |
| 6_26017542_C | HIST1H1A | 0.0011 | |
| 10_88930249_T | FAM35A | 0.0012 |