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. 2022 Apr 8;9:289–300. doi: 10.2147/JHC.S352948

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© 2022 Niu et al.

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TRAPPC5 knockdown inhibited HCC cell proliferation, migration, and invasion. (A) The down-regulation effect of four siRNAs (S1-4) in two HCC cell lines (HCCLM3 and BEL-7404) were tested by qPCR and S1 was selected for further research. (B, C) TRAPPC5 downregulation significantly inhibited HCC cell proliferation as analyzed by CCK-8 assay and colony formation. (D, E) TRAPPC5 downregulation also suppressed HCC cell invasion and migration by wound healing assay and transwell assay. *P < 0.05.