Table 2.
PK Parameters (Mean ± SD) of DP303C, Total Antibody DP001, and Unconjugated MMAE After Administration of the First Dose of DP303C at 4.0 mg/Kg (90 min Intravenously)
| Group | t1/2 (h) | Cmax (μg/mL) | AUC0-∞ (h*μg/mL) | CL (mL/h/kg) | Vdss (mL/kg) |
|---|---|---|---|---|---|
| DP303c analyte | |||||
| 4 mg/kg | 136.8 ± 49.8 | 93.520 ± 10.810 | 6417 ± 1413 | 0.65 ± 0.14 | 74.77 ± 15.47 |
| Group | t1/2 (h) | Cmax (μg/mL) | AUC0-∞ (h*μg/mL) | CL (mL/h/kg) | Vdss (mL/kg) |
| DP001 analyte | |||||
| 4 mg/kg | 138.4 ± 45.6 | 103.742 ± 13.211 | 7333 ± 1591 | 0.57 ± 0.11 | 67.28 ± 11.50 |
| Group | t1/2 (h) | Tmax (h) | Cmax (ng/mL) | AUC0-C (h*ng/mL) | |
| MMAE analyte | |||||
| 4 mg/kg | 235.1 ± 70.4 | 52 ± 18 | 0.059 ± 0.015 | 21.13 ± 6.84 | |
Abbreviations: AUC0-∞, area under the concentration–time curve from time zero to infinity; Cmax, maximum concentration; CL, clearance; Vdss, volume of distribution at steady state; Tmax, time to Cmax; t1/2, terminal half-life; SD, standard deviation.