Table 4. The GO enrichment terms of the potential susceptibility genes in each optimized brain region identified by S-PrediXcan, eDESE:gene and eDESE:isoform.
| Tissue name | *S-PrediXcan | eDESE:gene | eDESE:isoform |
|---|---|---|---|
| Brain-Anterior cingulate cortex (BA24) | - | Regulation of gap junction assembly (BP) | Potassium ion transmembrane transporter activity (MF); potassium: chloride symporter activity (MF); nervous system development (BP); generation of neurons (BP); neurogenesis (BP) |
| Brain-Cerebellum | Ion binding (MF); cation binding (MF); metal ion binding (MF); intracellular organelle (CC) | Dendrite (CC); dendritic tree (CC); neuron projection (CC); postsynapse (CC); synapse (CC) | Voltage-gated calcium channel activity involved in cardiac muscle cell action potential (MF); nervous system development (BP) |
| Brain-Frontal Cortex (BA9) | Intracellular organelle (CC); intracellular membrane-bounded organelle (CC) | Somatodendritic compartment (CC); dendrite (CC); dendritic tree (CC); synaptic vesicle membrane (CC); exocytic vesicle membrane (CC) | - |
| Brain-Hippocampus | Ion binding (MF) | - | Postsynaptic density (CC); asymmetric synapse (CC) |
| Brain-Spinal cord (cervical c-1) | - | High voltage-gated calcium channel activity (MF); voltage-gated calcium channel activity involved in AV node cell action potential (MF); regulation of B cell tolerance induction (BP); positive regulation of B cell tolerance induction (BP); L-type voltage-gated calcium channel complex (CC) | Nitrogen compound transport (BP); organelle (CC) |
*
MF: Molecular Function terms of GO. BP: Biological Process terms of GO. CC: Cellular Component terms of GO.