Table 6. The enrichment of drug-gene interaction terms in DGIdb for the susceptibility genes identified by MAGMA, S-PrediXcan and eDESE.
Models | # of antipsychotics-gene interaction terms | # of total drug-gene interaction terms | Enrichment p* |
---|---|---|---|
MAGMA | 57 | 937 | 1.62e-11 |
S-PrediXcan | 12 | 452 | 0.33 |
eDESE:dist | 34 | 279 | 1.56e-15 |
eDESE:gene | 56 | 968 | 1.65e-10 |
eDESE:isoform | 70 | 1,104 | 8.74e-15 |
Enrichment p denotes the p-value of the hypergeometric distribution test. See also Table 6—source data 1, Table 6—source data 2, Table 6—source data 3, Table 6—source data 4, and Table 6—source data 5.