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. 2022 Mar 31;54(4):437–449. doi: 10.1038/s41588-022-01016-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — Panel (a) plots the relative accuracy (RA) with error bars representing confidence intervals with + /− 1 standard error. Panel (b) plots the proportion of the loss of accuracy (LOA) explained by LD and MAF calculated as 100% × (1 − RA_pred(LD+MAF))/(1 − RA_obs) with error bars representing confidence intervals with + /− 1 standard error. RA refers to the European genetic ancestries to African genetic ancestries ratio of prediction accuracies (R²) of PGIs trained in a large sample of European-genetic-ancestry UKB participants (N = 425,231). The accuracy in European-genetic-ancestry participants was assessed in a holdout sample of 10,000 unrelated individuals, while the accuracy in African-genetic-ancestry participants was assessed in a holdout sample of 6,514 unrelated individuals. Phenotype labels: EA (Educational Attainment), Height (standing height), BMI (body mass index), LDL (low-density lipoprotein cholesterol), HDL (high-density lipoprotein cholesterol), TG (triglycerides), ASTHMA (diagnosed asthma), T2D (diagnosed type 2 diabetes) and HTN (diagnosed hypertension). See Supplementary Note section 7 in Wang et al. for additional details. Data underlying this Figure are reported in Supplementary Table 5.