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. 2022 Mar 31;54(4):437–449. doi: 10.1038/s41588-022-01016-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — The meta-analysis was conducted by combining summary statistics from (pooled-sex) association analyses conducted in UK Biobank (N = 440,817 individuals) and 23andMe (N = 2,272,216 individuals); see Supplementary Note section 3.4 for details. Panel (a): Manhattan plot, in which P values are based on summary statistics adjusted for inflation using the LD score intercept estimated from an autosomal association analysis of UKB and 23andMe. The solid line indicates the threshold for genome-wide significance (P = 5 × 10⁻⁸ based on a two-sided Z-test adjusted for multiple comparisons). Panel (b): Q-Q plot, in which P values are based on unadjusted Z-test statistics. The dotted line represents the expected -log₁₀(P-values) under the null hypothesis. The (barely visible) gray shaded area in represents the 95% confidence intervals under the null hypothesis.