Table 2.
The Association Between Age and Immunological Responses & Pulmonary Lesions in TB Patients with or without Diabetes Mellitus
| TB-NDM (n = 159) | Total | TB-DM (n = 168) | Total | |||
|---|---|---|---|---|---|---|
| Age < 60 Years (n = 115) | Age ≥ 60 Years (n = 44) | Age < 60 Years (n = 87) | Age ≥ 60 Years (n = 81) | |||
| IGRA-ELISPOT | ||||||
| Positive (%) | 42 (36.52%) | 22 (50.00%) | 64 | 40 (45.98%) | 36 (44.44%) | 76 |
| Negative (%) | 16 (13.91%) | 17 (38.64%) | 33 | 15 (17.24%) | 26 (32.10%) | 41 |
| IGRA-ELISA | ||||||
| Positive (%) | 29 (25.22%) | 2 (4.55%) | 31 | 17 (19.54%) | 10 (12.35%) | 27 |
| Negative (%) | 28 (24.35%) | 3 (6.81%) | 31 | 15 (17.24%) | 9 (11.11%) | 24 |
| 38kD+16kD | ||||||
| Positive (%) | 30 (26.09%) | 13 (29.55%) | 43 | 29 (33.33%) | 22 (27.16%) | 51 |
| Negative (%) | 85 (73.91%) | 31 (70.45%) | 116 | 58 (66.67%) | 59 (72.84%) | 117 |
| Pulmonary lobe lesion | ||||||
| Mild (1–2 lobes) (%) | 70 (60.87%) | 27 (61.36%) | 97 | 42 (48.28%) | 44 (54.32%) | 86 |
| Severe (3–5 lobes) (%) | 45 (39.13%) | 17 (38.64%) | 62 | 45 (51.72%) | 37 (45.68%) | 82 |
| Pulmonary cavity | ||||||
| NO (%) | 98 (85.22%) | 34 (77.27%) | 132 | 66 (75.86%) | 55 (67.90%)α** 2.725 [1.390, 5.249]※※ |
121β* 1.899 [1.109, 3.296]※ |
| Yes (%) | 17 (14.78%) | 10 (22.73%) | 27 | 21 (24.14%) | 26 (32.10%) | 47 |
Notes: Results between each two groups were compared using the Chi-square test or Fisher’s exact test according to the sample size. *: P = 0.0242, **: P = 0.0050. P-value < 0.05 was considered as a significant difference. α: P value from Age < 60 years TB-NDM group vs Age ≥ 60 years TB-DM group; β: P value from TB-NDM group vs TB-DM group. ※※ The odds ratios (ORs) and their 95% confidence interval (CI) were calculated by Baptista–Pike method.