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. 2022 Apr 13;3(6):371–387.e9. doi: 10.1016/j.medj.2022.04.001

Figure 3.

Figure 3

The effect of IFN-λ on fecal viral RNA shedding

(A) Percentage of participants with detectable fecal SARS-CoV-2 RNA across each of the study arms, as evaluated using the logistic GEE model described in the statistical methods section (STAR Methods). The x axis marks the time point in the study: days 3 (range 0–7), 14 (8–21), and 28 (22–35). The y axis indicates the percentage of participants with detectable fecal SARS-CoV-2 RNA. The blue bar corresponds to participants in the placebo control arm, and the orange bar corresponds to participants in the IFN-λ intervention arm. Each bar also marks the 95% CI. Number of participants and percentage of participants that provided a positive stool sample are listed above each stacked bar in black and red fonts, respectively, and summarized in Data S1.

(B) Odds ratio comparing detectable fecal SARS-CoV-2 RNA shedding in the IFN-λ intervention arm with the placebo arm at each time point in the first month of the study. The x axis marks the odds ratio adjusted for age, sex, collection kit type (OG or ZY), and target gene (E, N1, N2, or RdRP) (aOR). The y axis marks the time point in the study: days 3 (range 0–7), 14 (8–21), and 28 (22–35). The point marks the aOR, flanked by lines denoting the 95% CIs. The red dashed vertical line at aOR = 1.0 indicates no association.