Figure 4.

Association between fecal viral RNA shedding and symptoms

We present these results in the overall population, as well as stratified by the presence and absence of ongoing viral RNA shedding from the oropharynx (OP).

(A) Summary of the association between viral RNA shedding and report of a given symptom in all participants. Shedding and symptom data from up to day 28 were included in this analysis. Adjusted odds ratios (aOR) for this association were evaluated using the logistic GEE model described in the statistical methods section (STAR Methods), which averages over collection kits (OG and ZY), target genes (E, N1, N2, and RdRP) and technical replicates and is adjusted for age, sex, collection kit, and target gene. The x axis indicates the aOR for the presence of a given symptom. The y axis lists symptoms divided into those associated with the GI tract and those not associated with the GI tract. The odds ratio for each symptom is indicated by the circle, and associated bars represent the 95% CI. The red dashed vertical line at aOR = 1.0 indicates no association. The percentage of surveys reporting each symptom is provided to the left of these bars. aOR and the 95% CIs are listed to the right of the bars. Analyses where sample size was insufficient are listed as “Too few reports.”

(B and C) Identical data to (A) where (B) lists participants with negative paired OP swabs for SARS-CoV-2 RNA, and (C) lists participants with positive paired OP swabs for SARS-CoV-2 RNA.