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. 2022 Apr 12;13:1925. doi: 10.1038/s41467-022-29203-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a A schematic showing the tumor and normal cell line mixing approach for simulating low-purity sample pairs. b and c Heatmaps showing the b specificity and c sensitivity of DASH to capture HLA LOH in simulated samples of differing purity and clonality. Dark blue denotes high sensitivity or specificity, light blue denotes low sensitivity or specificity and gray denotes no data. Source data are provided with this paper.