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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: J Thorac Cardiovasc Surg. 2021 Oct 13;164(6):e371–e384. doi: 10.1016/j.jtcvs.2021.07.062

Figure 2: Perivascular fibrosis reduced with EV-treatment.

Figure 2:

The ischemic myocardial territory was examined for (A) perivascular collagen, (B) interstitial collagen, and (C) muscle fiber areas by Picrosirius Red staining technique. Five areas at 10x magnification per animal were measured and analyzed by 2-way ANOVA. Western blots of protein lysates from porcine ischemic myocardial tissue were performed as indicated with quantitative analyses normalized to α-tubulin and representative images (D) COL1A1 and (E) COL3A1. (F) Ratio of COL3A1 to COL1A1. Data is graphed as mean with SEM. COL1A1, collagen I type 1; COL3A1, collagen III type 1.