Western blots of protein lysates from porcine ischemic myocardial tissue were performed as indicated with quantitative analyses normalized to α-tubulin and representative images. Data is graphed as mean with SEM, with main effect of diet as large bracket and main effect of EVs as inner brackets. AMPK, AMPK-activated protein kinase; mTORC1, mechanistic target of rapamycin complex 1; GSK3β, glycogen synthase kinase 3 β; PGC1α, PPARG coactivator 1α; SIRT1, sirtuin 1; AT1R, angiotensin II receptor type 1; AT2R, angiotensin II receptor type.