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. 2022 Apr 12;12:6117. doi: 10.1038/s41598-022-09825-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Unadjusted box plots of normalized protein expression levels (NPX) of six proteins significantly associated with APOE2 genotype, by age group. White boxplots = individuals who are homozygous for the major allele, gray boxplots = heterozygotes, black boxplots = minor allele homozygotes. Box plot midline = median value, lower/upper hinges = 25th and 75th percentiles, respectively; lower whisker ends/upper whisker ends no further than 1.5× interquartile range from the hinge. Data beyond whiskers are outlying points. LDLR low-density lipoprotein receptor, HMOX1 heme oxygenase-1, SLAMF8 SLAM family member 8, RNF31 E3 ubiquitin-protein ligase RNF31, CNTNAP2 contactin-associated protein-like 2, SRP14 signal recognition particle 14 kDa protein.