Table 2.
Results of sex-specific analysis and sex-SNP interaction analysis of PICALM variant rs3851179 in the ADGC.
| Sex-stratified resultsa | Beta | Std error | p-value | MAF |
|---|---|---|---|---|
| Male model 1 | − 0.206 | 0.035 | 5.62E−09 | 0.358 |
| Male model 2 | − 0.176 | 0.038 | 4.08E−06 | 0.359 |
| Female model 1 | − 0.083 | 0.029 | 4.37E−03 | 0.354 |
| Female model 2 | − 0.087 | 0.031 | 5.60E−03 | 0.352 |
| Interaction resultsb | Interaction beta | Std error | p-value | MAF |
|---|---|---|---|---|
| Model 1 | 0.116 | 0.044 | 8.05E−03 | 0.354 |
| Model 2 | 0.372 | 0.048 | 7.84E−02 | 0.354 |
N = 9135 cases (60% female), 9,677 controls (60% female).
aModel 1: adjusted for age, sex, and PCs; Model 2: adjusted for age, sex, PCs, and APOE genotype.
bModel 1: adjusted for age and PCs; Model 2: adjusted for age, PCs, and APOE.