TABLE 1.

: Descriptive statistics of variables used in the models

Variable	Level	Median (IQR) or n (%)
Age		55 (10)
Sex	Female	94,310 (54.9)
Education	No graduate degree	118,191 (69.7)
Deprivation		–2.3 (3.8)
Alcohol consumption	Daily or almost daily	35,989 (21.0)
	Three or four times a week	39,747 (23.2)
	Once or twice a week	43,815 (25.6)
	Once to three times a month	18,149 (10.6)
	Only special occasions	19,673 (11.5)
	Never	14,024 (8.2)
Smoking	Current smoker	16,412 (9.6)
	Previous smoker	63,372 (37.1)
	Non‐smoker	91,091 (53.3)
Physical activity	Strenuous	13,577 (8.5)
	Moderate	103,121 (64.7)
	Light	42,777 (26.8)
BMI	<18.5	768 (0.45)
	18.5–25	3372 (2.0)
	25–30	51,649 (30.2)
	30–35	74,192 (43.4)
	35–40	31,807 (18.6)
	>40	9070 (5.3)
Data provider	England (Vision)	14,036 (8.2)
	Scotland	18,758 (10.9)
	England (TPP)	123,133 (71.7)
	Wales	15,848 (9.2)
Dementia diagnosis		2124 (1.2)
Prior depression		13,136 (7.6)
Prior stroke		1598 (0.9)
Prior diabetes		4034 (2.3)
Prior hypercholesterolemia		4901 (2.9)
Prior hypertension		16,152 (9.4)
Number of prior comorbidities		18 (40)
Total number of prescriptions*		3 (12)
APOE carrier	ε2	21,626 (12.9)
	ε3	102,740 (61.3)
	ε4	43,199 (25.8)

^*The total number of prescriptions was used along the number of anticholinergic drugs to calculate the scale‐specific non‐anticholinergic drug count.

Abbreviations: APOE, apolipoprotein E; BMI, body mass index; IQR, interquartile range; TPP, The Phoenix Partnership.