Figure 1.

Analysis of individual dGAE filaments from a topographical AFM height image. (a) A typical AFM image of dGAE fibrils² with an inset showing a 2× magnified view. Arrows point to the fibrils shown in (b) and (c). Scale bar represents 500 nm. (b) Digitally straightened images showing a typical dGAE fibril and typical fibril bundles. Scale bar represents 200 nm. (c) Digitally straightened AFM image of a canonical dGAE tau fibril together with a 3D reconstructed surface envelope model. Scale bar represents 50 nm. (d) The central line height profile of the fibril image shown in (c).