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. 2022 Apr 15;434(7):167466. doi: 10.1016/j.jmb.2022.167466

Figure 2.

Figure 2

Simulation of topographic AFM height images from cryo-EM density maps. Cross-sectional views of axis-aligned cryo-EM density map iso-surfaces for (a) paired helical filaments (EMD-0259) and (c) ‘heparin-snake’ (EMD-4563) tau fibrils are shown with the position of the helical axis (+). Simulated topographic images of 500 nm fibril segments and the top view of extended 250 nm segments of iso-surfaces aligned to the simulated images are shown for PHF in (b) and ‘heparin-snake’ in (d). All scale bars represent 10 nm.