Figure 3.

Comparison of the typical experimental AFM height image of dGAE tau fibril with topographical images of tau amyloid fibril polymorphs. The tau fibril polymorphs were simulated with identical tip (radius here estimated to be 11.7 nm) and sampling parameters using extended and axis-aligned cryo-EM map iso-surfaces. The ‘*’ indicate image data shown in Figure 1(c). Length of the scale bar is 50 nm. The simulated images have been aligned to the same estimated helical axis height position as the experimental data image and, therefore, have comparable height colour coding. The EMDB accession codes of the cryo-EM density maps from which the topographs were simulated from are listed with the abbreviated names of the individual filaments. The sample origin is noted above the filaments’ images. The following abbreviations were used for disease diagnoses and filament labels: CBD – corticobasal degeneration, CTE – chronic traumatic encephalopathy, PiD – Pick’s disease, AD – Alzheimer’s disease, NPF – narrow Pick filament, WPF – wide Pick filament, PHF – paired helical filament, SF – straight filament.