Figure 4.

Comparison of the cross-section of the surface envelope model derived from the experimental AFM dGAE filament image and cryo-EM density map cross-sections. The cross-sections for the CTE type II filaments (a) and PHF from AD patient tissue (b), as well as in vitro assembled heparin-induced ‘twister’ filaments (c) are shown. The average cross-section of the AFM image derived 3D model is shown as thick blue lines, and the structural variation observed along the fibril in the AFM image is indicated by the thin blue lines denoting the 2.5 and 97.5 percentile bounds. The cryo-EM density cross-sections are shown in grey.