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. 2022 Mar 30;9:800918. doi: 10.3389/fcvm.2022.800918

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Copyright © 2022 Spione, Arevalos, Gabani, Sabaté and Brugaletta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagnostic algorithm for no obstructive and obstructive coronary artery disease. CAD, coronary artery disease; FFR, fractional flow reserve; CFR, coronary flow reserve; IMR, index of microvascular resistance; hyperemic microvascular resistance. Positive Acetylcholine Test: >90% reduction in epicardial coronary artery with angina and ECG modifications.