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. 2022 Mar 30;9:852009. doi: 10.3389/fcvm.2022.852009

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Copyright © 2022 Yang, Xu, Zhou, Xue, Gao, Li, Sun, Yang, Liu, Zhao, Luo, Zeng, Zheng and Xiong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes of betaine between first and second hospitalization and the association between Δbetaine and ΔN-terminal pro-brain natriuretic peptide (NT-proBNP). (A) Demonstration of plasma levels of betaine after further guideline-recommended treatment in all PH participants (n = 203). Data were compared using paired-samples t-tests. **p < 0.001. (B) The positive association between Δbetaine and ΔNT-proBNP. Δbetaine and ΔNT-proBNP were defined as the value at the second admission visit minus the baseline value. Spearman’s correlation (2-tailed) was used for analysis.