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. 2022 Mar 30;9:852009. doi: 10.3389/fcvm.2022.852009

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Copyright © 2022 Yang, Xu, Zhou, Xue, Gao, Li, Sun, Yang, Liu, Zhao, Luo, Zeng, Zheng and Xiong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ΔBetaine was associated with the prognosis of patients with PH. Patients were divided into two groups according to Δbetaine >0 or Δbetaine ≤0. Follow-up duration was defined from the second betaine measurement to the occurrence of outcomes or the end of follow-up. In this analysis, outcome events occurred in 23 patients between two measurement points, so these patients were excluded. Finally, a total of 180 patients with PH were included for exploration. Value of p calculated by the log-rank test.