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. 2022 Mar 30;13:876515. doi: 10.3389/fimmu.2022.876515

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Copyright © 2022 Hasegawa, Oka and Demehri

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Type 2 alarmin cytokines orchestrate immune responses in the skin. Epidermis-derived TSLP, IL-25, and IL-33 act as alarmins to instigate cutaneous type 2 immunity through a complex and pleiotropic network of innate and adaptive immune cells. In addition, TSLP and IL-33 provoke sensory neurons to mediate itch and pain responses. DC, dendritic cell; ILC2, group2 innate lymphoid cell; LC, Langerhans cell; TSLP, thymic stromal lymphopoietin; TSLPR, thymic stromal lymphopoietin receptor. Created with BioRender.com.