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. 2022 Mar 30;13:876515. doi: 10.3389/fimmu.2022.876515

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Copyright © 2022 Hasegawa, Oka and Demehri

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Type 2 alarmin cytokines exhibit pro-homeostatic properties in the skin. The function of type 2 alarmin cytokines extends beyond their conventional Th2-associated function in host defense and allergy. In the skin, these cytokines play critical roles in cancer regulation and sebum secretion. ILC, innate lymphoid cell; MRSA, methicillin-resistant Staphylococcus aureus; ROS, reactive oxygen species; TSLP, thymic stromal lymphopoietin; TSLPR, thymic stromal lymphopoietin receptor. Created with BioRender.com.