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Estrogen signaling pathway with therapeutic targets of repurposed drugs for pulmonary arterial hypertension therapy. COMT = catechol-O-methyltransferase; CYPs = cytochrome P450 enzymes; CYP1B1 = cytochrome P450 family 1, subfamily B, member 1; DHEA = dehydroepiandrosterone; 3β-HSD = 3β-hydroxysteroid dehydrogenase.
