Table 3.
Univariate and multivariate analysis for the initiation of anticoagulation at discharge in patients without systemic bleeding during hospitalization.
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Non-anticoagulant group (n = 8,498) | Anticoagulant group (n = 6,057) | P value | OR | (95% CI) | P value | |
| Age, years, Mean ± SD | 78 ± 9 | 75 ± 9 | <0.001 | 0.980 | (0.970–0.978) | <0.001 |
| Male, n (%) | 4,389 (51.6) | 3,375 (55.7) | <0.001 | 1.011 | (0.385–1.119) | 0.832 |
| Prior medical history | ||||||
| Ischemic stroke/TIA, n (%) | 2,488 (29.3) | 1,638 (27.0) | 0.003 | 0.875 | (0.811–0.949) | 0.005 |
| Hemorrhagic stroke, n (%) | 297 (3.5) | 116 (1.9) | <0.001 | 0.582 | (0.468–0.723) | <0.001 |
| Gastrointestinal bleeding, n (%) | 173 (2.0) | 67 (1.1) | <0.001 | 0.546 | (0.411–0.725) | <0.001 |
| Urinary tract bleeding, n (%) | 3 (0) | 2 (0) | 0.942 | - | ||
| Smoking, n (%) | 1,949 (22.9) | 1,608 (26.5) | <0.001 | 1.027 | (0.723–1.733) | 0.369 |
| Anticoagulants, n (%) | 482 (5.7) | 1,123 (18.5) | <0.001 | 3.525 | (3.152–3.939) | <0.001 |
| New comorbidity during hospitalization | ||||||
| Hypertension, n (%) | 6,983 (82.2) | 5,000 (82.5) | 0.557 | - | ||
| Diabetes, n (%) | 1,597 (18.8) | 1,162 (19.2) | 0.552 | - | ||
| Dyslipidemia, n (%) | 2,982 (35.1) | 2,284 (37.7) | 0.001 | 1.026 | (0.782–1.088) | 0.611 |
| Pneumonia, n (%) | 2,685 (31.6) | 1,007 (16.6) | <0.001 | 0.583 | (0.535–0.635) | <0.001 |
| Coronary heart disease, n (%) | 1,797 (21.1) | 1,105 (18.2) | <0.001 | 0.919 | (0.845–1.034) | 0.109 |
| Heart failure, n (%) | 347 (4.1) | 174 (2.9) | <0.001 | 0.931 | (0.799–1.881) | 0.601 |
| Renal Insufficiency, n (%) | 839 (9.9) | 477 (7.9) | <0.001 | 0.847 | (0.754–0.966) | 0.021 |
| Peripheral artery disease, n (%) | 347 (4.1) | 286 (4.7) | 0.063 | - | ||
| Anemia, n (%) | 369 (4.3) | 189 (3.1) | <0.001 | 0.836 | (0.702–1.066) | 0.104 |
| Tumor, n (%) | 603 (7.1) | 386 (6.4) | 0.088 | - | ||
| Deep vein thrombosis, n (%) | 238 (2.8) | 223 (3.7) | 0.003 | 1.631 | (1.365–1.950) | <0.001 |
| SBP, mmHg, Mean ± SD | 151 ± 24 | 148 ± 23 | <0.001 | 0.998 | (0.996–0.999) | 0.006 |
| DBP, mmHg, Mean ± SD | 85 ± 15 | 85 ± 14 | 0.855 | - | ||
| Baseline NIHSS score, Median (IQR)* | 6 (2–14) | 3 (1–7) | <0.001 | 0.941 | (0.934–0.946) | <0.001 |
| Reperfusion therapy, n (%) | 1,442 (17.0) | 1,058 (17.5) | 0.432 | - | ||
| Length of stay, days, Median (IQR) | 10 (8–14) | 11 (9–15) | <0.001 | 1.047 | (1.042–1.053) | <0.001 |
CI indicates confidence interval; DBP, diastolic blood pressure; IQR, interquartile range; NIHSS, national institutes of health stroke scale; OR, odds ratio; SD, standard deviation; SBP, systolic blood pressure; TIA, transient ischemic attack.
*
NIHSS was available for 12,342 patients (5,324 in anticoagulant group and 7,018 in non-anticoagulant group).