Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 30;12:868407. doi: 10.3389/fcimb.2022.868407

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Yu, Li, Zhou, Liu, He, Huang, Wu, Zhu, Yu, Yao, Zhang and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Detection of viral load in serum and brain and description of brain histopathological damage after infection of SV129 and SV129 (Vim-KO) mice with dengue virus (DENV)-2. (A, B) Changes in the viral load in the brain and serum; *P < 0.05; **P < 0.01; ***P < 0.001. (C, D) Brain histopathological section on the 5th day after infection in SV129 and SV129 (Vim-KO) mice. (C) Left: the cortical stratifications disappeared, with a large number of apoptotic pyknotic cells (black arrow). Right: the hippocampus displayed apoptotic pyknosis of glial cells (black arrow) and local cerebral liquefactive necrosis (black circled). (D) Left: the cortical stratification was normal, and apoptotic pyknosis of glial cells (black arrow) was found in all six cortical layers. Right: the hippocampus (black square) showed no obvious abnormalities.