Figure 4.

(A) Schematic illustration of human CARD9 protein structure and reported disease-associated CARD9 mutations. (B) Relation between CARD9 mutations and diseases from N-terminus to C-terminus. Symbols in green represent the CARD9 mutations in CARD domain. Symbols in yellow indicate the CARD9 mutations in coiled-coil domain. Symbols in blue indicate the CARD9 mutations in the region between CARD domain and coiled-coil domain. The diseases associated with individual mutations are shown in the middle in pink.