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. 2022 Apr 12;12(4):e802. doi: 10.1002/ctm2.802

FIGURE 8.

FIGURE 8

Characteristics of the cross‐reactive T‐cell response quality between SARS‐CoV‐2 and endemic coronaviruses. (A) Bar graph represents the SE‐specific T‐cell response in each CD4+ (left panel) and CD8+ (right panel) T‐cell subsets. The table shows the percentage of responders considering a responder subjects as those with the percentage of SE‐specific T‐cells higher than 0.05% considering the sum of IFN‐γ, TNF‐α and IL‐2 production. (B) Correlation between S‐Specific and SE‐specific CM CD4+ T‐cell levels. (C) Correlation between S‐Specific and SE‐specific EM CD4+ T‐cell levels and (D) correlation between S‐Specific and SE‐specific CM CD8+ T‐cell levels in healthy donors. (E) Pie graphs represent IFN‐γ, IL‐2 and TNF‐α expression in each T‐cell subset, where median percentages of this expression are shown in right table. (F) Correlation between S‐Specific and SE‐specific MEM CD4+ IL‐2+ T‐cells and (G) S‐specific and SE‐specific CM CD8+ IL‐2+ T‐cell levels. Each dot represents an individual. ROUT method was utilised to identify and discard outliers. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Mann–Whitney U‐test was used for groups’ comparisons and Spearman test for non‐parametric correlations. (HD, n = 33)