TABLE 3.
Diagnostic performance of the CXCL10 mRNA release assay and T-SPOT.TB assay for Mycobacterium tuberculosis (M.tb) infection.
| Sensitivity% (95% CI) | Specificity% (95% CI) | NPV% (95% CI) | PPV% (95%CI) | LR + (95% CI) | LR- (95% CI) | |
| CXCL10 mRNA release assay | 93.9 (90.8–96.2) | 98.0 (94.3–99.6) | 87.6 (82.4–91.5) | 99.1 (97.2–99.7) | 47.6 (15.5–145.9) | 0.06 (0.04–0.09) |
| T-SPOT.TB | 94.5 (91.5–96.6) | 100.0 (97.6–100.0) | 88.9 (83.8–92.5) | 100.0 (100.0–100.0) | /† | 0.05 (0.06–0.09) |
| CXCL10 or T-SPOT.TB* | 97.4 (95.1–98.8) | 98.0 (94.3–99.6) | 94.3 (89.7–96.9) | 99.1 (97.3–99.7) | 49.3 (16.1–151.3) | 0.03 (0.01–0.05) |
NPV, negative predictive value; PPV, positive predictive value; LR+, likelihood ratio for positive test; LR−, likelihood ratio for negative value.
*The positive result was assumed when either test was positive, and a negative result was assumed when both tests were negative.
†The LR + was unavailable when the diagnostic specificity was 100%.