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. 2022 Mar 30;12:870721. doi: 10.3389/fonc.2022.870721

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Copyright © 2022 Zhou, Li, Guan, Zhou, Zhu, Wang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The WGCNA R package was used for finding clusters (modules) of highly correlated genes. (A) Scale-free fitting index and the average connectivity at different soft threshold powers were analyzed. In summary, 5 was the most suitable power. (B) The co-expression module was created. Each branch represents a gene, and each color below represents a co-expression module. (C) Cluster dendrogram of module eigengenes. (D) Heatmap analysis of the correlation between module characteristic genes and traits showed that the dark green module negatively correlated with stage and distant metastasis of patients with CRC (absolute value of cor >0.2, p < 0.05). (E, F) Scatter plot of dark green module members (MM) and gene significance (GS). A significant correlation was found between GS and MM (cor >0.4, p < 0.0001).