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. 2022 Mar 30;16:863342. doi: 10.3389/fncel.2022.863342

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Copyright © 2022 Lu, Wan, Liu, Jin, Chu, Bing and Qiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of nitric oxide synthase abolished the facial stimulation-induced MF-GrC LTP in the mouse cerebellar cortex. (A) Upper: Representative extracellular recording traces showing a paired air-puff stimulation (10 ms, 60 psi, 50 ms interval) evoked MF-GrC synaptic responses before (pre) and after (post) delivery of 20-Hz (240 pulses) air-puff stimuli in the presence of nitric oxide synthase inhibitor, i.e., L-NNA (200 μM). (B) Summary of data showing the time course of normalized amplitude of N1 in which the 20-Hz stimuli protocol (arrow) was delivered in the presence of L-NNA. (C) Mean value (± SEM) with individual data showing the normalized amplitude before (pre) and after (post) the delivery of the 20-Hz stimulation protocol in the presence of L-NNA. (D) Mean value (± SEM) with individual data showing the normalized N2/N1 ratio before (pre) and after (post) the delivery of the 20-Hz stimulation protocol in the presence of L-NNA. Note that inhibiting nitric oxide synthase abolished the 20-Hz facial stimulation-induced MF-GrC LTP. n = 7 recordings from 7 mice.