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. 2022 Mar 30;16:863342. doi: 10.3389/fncel.2022.863342

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Copyright © 2022 Lu, Wan, Liu, Jin, Chu, Bing and Qiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Application of NO donor produced MF-GrC LTP, which prevented the 20-Hz stimulation protocol-induced LTP of MF-GrC synaptic transmission. (A) Upper: Representative extracellular recording traces showing a paired air-puff stimulation (10 ms, 60 psi, 50 ms interval) evoked MF-GC synaptic responses before (pre-SNAP) and after (post-SNAP) application of NO donor, i.e., SNAP (500 μM; gray), and after delivery of the stimulation train (poststimuli). (B) Summary of data showing the time course of normalized amplitude of N1 before and after application of SNAP (100 μM; gray) and after delivery of the stimulation train (arrow). (C) Mean value (± SEM) with individual data showing the normalized amplitude before (pre-SNAP) and after (post-SNAP) application of SNAP and after the stimulation train (poststimuli). (D) Mean value (± SEM) with individual data showing the normalized N2/N1 ratio before (pre-SNAP) and after (post-SNAP) application of SNAP and after delivery of the stimulation train (poststimuli). Note that perfusion of NO donor produced an LTP of MF-GrC synaptic transmission and prevented the 20-Hz facial stimuli-induced MF-GrC LTP. * P < 0.05 vs. pre; n = 9 recordings from 9 mice.