TABLE 1.
Significantly enriched pathways with functions in follicle development.
| Pathway ID | Pathway term | Target gene list |
|---|---|---|
| gga01100 | Metabolic pathways | NADK, MSMO1, ASL2, PCK1, ST6GAL2, NSDHL, ST6GAL1, DHTKD1, SMPD1, PGAM1, PLA2G4A, CYP27A1, GCNT2, ACAT2, MGAT5B, BCO1, NDUFA12, GLO1, PLCB2, ISYNA1, CRYL1, CYP21A1, PIGK, MAN2A2, PIGS, PHGDH, GGT5, BLVRA, GALNT7, HPSE, NME6, INPP5D, GALNT10, PIP5K1B, CDS2, INPP5K, ELOVL6, CYP26A1, ATP6V1C2 |
| gga04510 | Focal adhesion | PGF, LAMA1, LAMA2, PDGFC, VAV3, PARVG, CAPN2, COL6A2, EGF, THBS4 |
| gga04916 | Melanogenesis | PLCB2, FZD4, GNAO1, WNT6, EDN1, WNT16 |
| gga00562 | Inositol phosphate metabolism | PIP5K1B, PLCB2, INPP5K, INPP5D, ISYNA1 |
| gga00510 | N-glycan biosynthesis | MGAT5B, ST6GAL2, MAN2A2, ST6GAL1 |
| gga04070 | Phosphatidylinositol signaling system | PIP5K1B, PLCB2, INPP5K, INPP5D, CDS2 |
| gga00620 | Pyruvate metabolism | GLO1, ACAT2, PCK1 |
| gga00830 | Retinol metabolism | PNPLA4, BCO1, CYP26A1 |
| gga04512 | ECM–receptor interaction | LAMA1, LAMA2, COL6A2, THBS4 |
| gga04010 | MAPK signaling pathway | PGF, TGFA, PDGFC, CSF1R, MAPK12, PLA2G4A, EGF |
| gga04150 | mTOR signaling pathway | ATP6V1C2, SLC7A5, FZD4, WNT6, WNT16 |
| gga04933 | AGE-RAGE signaling pathway in diabetic complications | EDN1, PLCB2, PRKCZ, MAPK12 |
| gga04080 | Neuroactive ligand–receptor interaction | OPRM1, CCKAR, LEPR, GRIN2C, NPY2R, EDN1, MC5R, P2RX7 |
| gga04060 | Cytokine–cytokine receptor interaction | CCL4, CSF1R, IL18R1, LEPR, TNFRSF11B, CXCL14 |
| gga00100 | Steroid biosynthesis | MSMO1, NSDHL |
| gga01230 | Biosynthesis of amino acids | ASL2, PHGDH, PGAM1 |
| gga00514 | Other types of O-glycan biosynthesis | ST6GAL2, ST6GAL1 |
| gga00563 | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | PIGS, PIGK |
| gga03320 | PPAR signaling pathway | CYP27A1, PCK1, FABP3 |
| gga04270 | Vascular smooth muscle contraction | EDN1, PLCB2, PLA2G4A, RAMP2 |
| gga04068 | FoxO signaling pathway | MAPK12, PCK1, EGF, FBXO32 |
| gga04810 | Regulation of actin cytoskeleton | BRK1, PIP5K1B, VAV3, PDGFC, EGF |
| gga04261 | Adrenergic signaling in cardiomyocytes | PLCB2, MAPK12, PPP2R2C, ATP1B1 |
| gga00512 | Mucin-type O-glycan biosynthesis | GALNT7, GALNT10 |
| gga04217 | Necroptosis | PLA2G4A, HMGB1, SMPD1, CAPN2 |
| gga04145 | Phagosome | ATP6V1C2, THBS4, MARCO, DMB2 |
| gga04310 | Wnt signaling pathway | WNT16, PLCB2, FZD4, WNT6 |
| gga04540 | Gap junction | PLCB2, PDGFC, EGF, DRD1 |
| gga04912 | GnRH signaling pathway | PLCB2, PLA2G4A, MAPK12 |
| gga00260 | Glycine, serine, and threonine metabolism | PHGDH, PGAM1 |
| gga00380 | Tryptophan metabolism | DHTKD1, ACAT2 |
| gga00564 | Glycerophospholipid metabolism | CDS2, LPGAT1, PLA2G4A |