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Genome-wide CRISPR knock-out Srsf2P95H/+ screen. (A) Schematic outline of the pooled CRISPR knock-out Srsf2 screen. (B) Visualization of performance of sgRNA against genes mutated in MDS and MDS/myeloproliferative neoplasm at day 18 of the screen. Gray dots, all the sgRNA identified; red dots, sgRNA with FDR < .01 and β score <−2.
