Figure 5.

Genes from the cell-cycle and regulation of DNA replication pathways are both misspliced and negatively selected in Srsf2^P95H/+ cells. (A) Venn diagrams showing the overlap between the genes that are misspliced in the GM-CSF Srsf2^P95H/+ cells and the genes that are negatively selected at days 4, 11, and 18 of the Srsf2 CRISPR screen. (B) Pathway analysis showing that genes associated with cell-cycle and DNA replication regulation are misspliced and cause cell death when deleted in Srsf2^P95H/+ cells.