FIG. 3.
Efficacy of delayed therapy against disseminated C. albicans MY1055 infection in CY-treated, chronically immunosuppressed ICR mice. Mice were challenged i.v. with C. albicans MY1055 at 5.6 × 104 CFU/mouse (study 1) and 1.22 × 105 CFU/mouse (Study 2). Mice received first treatment 24 h after challenge (delayed therapy) and were treated i.p., q.d., for 7 days. Survival data were pooled from both studies (20 mice total). Mice were immunosuppressed throughout the experimental period (28 days). (A) Caspofungin; (B) AmB.