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. 2022 Feb 16;219(5):e20210562. doi: 10.1084/jem.20210562

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© 2022 Mysore et al.

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Figure S5. — Overlap and GO term enrichment of genes with CCR2⁺CX3CR1⁺ DP monocytes of the nephritic kidney and genes reported in tumor-associated monocytes. (A) Heatmap of cluster markers overexpressed in kidney DP cells (Kid DP) in comparison to spleen DP (Spl DP) cells plotted across clusters of Wt/KO Med, Ccr2 KO:EC, and Wt:EC. (B) GSEA-GO-Bp for those markers of Wt monocytes cultured on endothelium which were overexpressed in kidney in comparison to spleen DPs (Kid DP > Spl DP). OR, odds ratio. (C) GSEA-GO-Bp for those markers of Wt monocytes cultured with activated endothelial cells, which had higher expression in mMono3 than mMono1, mMono2, and mMonoDC populations identified in Zilionis et al. (2019).