| Methods |
24‐week double‐blind, parallel group, placebo controlled, randomized study |
| Participants |
Country: USA
Multi‐centre (27 sites) study with 208 participants, 37 men and 171 women, with possible or probable AD, or AD with cerebrovascular disease (but not vascular dementia)
Inclusion criteria: MMSE between 5 and 26 inclusive, residence in nursing home, at least one NPI symptom reported at a frequency of at least several times per week.
Exclusion: most concomitant medications were allowed except those with significant cholinergic or anticholinergic effects |
| Interventions |
1. placebo
2. donepezil 10 mg/day |
| Outcomes |
NPI‐NH
MMSE
CDR‐SB |
| Notes |
The group on donepezil took 5 mg/d for the first 4 weeks, followed by 10 mg/d for 20 weeks. |
