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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Biol Cell. 2021 Sep 27;113(12):507–521. doi: 10.1111/boc.202100035

FIGURE 7.

FIGURE 7

Decreased HDAC1 expression in aged islets results in increased p27KIP1 levels and impaired ability to respond to mitogenic signals. (A) Young β-cells have elevated HDAC1 levels. This increases deacetylation of the p27KIP1 promoter and decreases p27KIP1 expression. This allows the young β-cells to be responsive to mitogenic signals. (B) Aged β-cells have decreased HDAC1 levels. This increases acetylation of the p27KIP1 promoter and increases p27KIP1 expression. Aged β-cells become unresponsive to mitogenic signals. Figure designed using BioRender