Table 1.
- Psychiatric adverse events following COVID-19 vaccination.
| S.No | Author, year | Age/sex of patient | Name of vaccine received (vaccine type) | Reported psychiatric adverse event | Time lag for onset of adverse event after vaccination | Key clinical features |
|---|---|---|---|---|---|---|
| 1. | Takata et al. (2021) | 42/F | Second dose of ChAdOx1 nCoV-19 vaccine (Viral vector vaccine) | Altered mental status | Few days | Alert but disoriented to time, person and place, agitated with labile affect, hallucinations (visual and tactile) |
| 2. | Hilaire et al. (2021) | 54/M | Second dose mRNA-1273 vaccine (mRNA vaccine) | Altered mental status | 1 day | Altered mental status, headache and high fever. History of type 2 diabetes mellitus, atrial flutter, hypothyroidism, well-controlled seizure disorder, and a remote history of traumatic brain injury |
| 3. | Roberts et al. (2021) | 51/M | First dose of AstraZeneca vaccine (Viral vector Vaccine) | Altered Mental status | 10 days | Disoriented to time and place, disordered thought, labile mood, auditory hallucinations |
| 4. | Grover et al. (2022) | 18/F | First dose of AstraZeneca's Vaxzevria (Viral vector vaccine) | Psychosis | Same day | Irritability, irrelevant speech, decreased sleep, delusions of persecution and reference, visual hallucinations. |
| 5. | Flannery et al. (2021) | 20 s/F | First dose of the Pfizer-BioNTech COVID-19 vaccine (mRNA Vaccine) | Psychosis | 1 week | Decreased sleep, anxiety, auditory hallucinations, catatonia. |
| 6. | Reinfeld et al. (2021) | 31/M | First dose mRNA-based COVID-19 vaccine (mRNA Vacccine) | Psychosis | Not specified | Auditory hallucinations, grandiose and erotomaniac delusions. History of Schizotypal traits |
| 7. | Giné-Servén et al. (2021) | Not mentioned | AstraZeneca COVID-19 vaccine (Viral vector vaccine) | Psychosis (2 cases) | Acute (7 h and 12 days) | Cycloid psychosis-like phenotype and marked cognitive impairment |
| 8. | Yesilkaya et al. (2021) | 42/M | First dose of the BNT162b2 mRNA (mRNA vaccine) | Mania with psychotic symptoms | 1 day | Irritability; sleeplessness; dysphoric mood; increased psychomotor activity; persecutory and referential delusions; loosening of associations |
| 57/M | Second dose of the BNT162b2 mRNA vaccine (mRNA vaccine) | Mania with psychotic symptoms | Same day | Increased speech; increased psychomotor activity; decreased sleep; nihilistic delusion | ||
| 9. | Uvais (2021) | 74/M | First dose of ChAdOx1-S/nCoV- 19 vaccine (Viral vector vaccine) | Depression | 2 days | Low mood, dryness of mouth, lack of interest in activities, marked reduction in appetite, and difficulty in initiating sleep. |
| 10. | Ercoli et al. (2021) | 41/M | First dose | Functional neurological disorder | Same day | Bilateral facial paralysis Left-sided facial hypoesthesia which resolved spontaneously |
| 11. | Butler et al., 2021 | 38/F | First dose of the Pfizer-BioNTech SARS- CoV-2 vaccine (mRNA vaccine) | Functional neurological disorder | Same day | Left-sided arm weakness in distal muscles and forearm. Downward deviation of the angle of the mouth to the left and tongue deviation to the right. Hoover’s sign positive. |
| 36/F | Second dose dose of Moderna SARS-CoV-2 vaccine (mRNA Vaccine) | Functional neurological disorder | Same day | Weakness in right hand and new onset right-leg limping Hoover’s sign positive. |